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احمد محمدسعيد عبدالله جان
Document Details
Document Type
:
Article In Journal
Document Title
:
Hyperbaric oxygen results in increased vascular endothelial growth factor (VEGF) protein expression in rabbit calvarial critical-sized defects
الأكسجين عالي الضغط يسبب زيادة في عامل نمو بطانة الاوعية الدموية (VEGF) في العيوب ذات الحجم الحرج.
Subject
:
Oral and Maxillofacial Surgery
Document Language
:
English
Abstract
:
Background: Hyperbaric oxygen therapy (HBO) promotes osseous healing, however the mechanism by which this occurs has not been elucidated. HBO may promote angiogenesis, which is vital for bone healing. Vascular endothelial growth factor (VEGF) is one of the key factors that stimulates angiogenesis. Objective. The objective of this study was to investigate whether HBO altered VEGF expression during bone healing. Methods and materials: Archived samples from calvarial defects of rabbits exposed to HBO (2.4 ATA, 90 minutes a day, 5 days a week for 4 weeks) and normobaric oxygen controls (NBO) were analyzed by immunohistochemistry. Results: VEGF expression in 6-week HBO samples was elevated compared to NBO (P .012). Staining of the 12week HBO samples was reduced compared to 6-week HBO (P = .008) and was similar to 6- and 12-week NBO control samples. Conclusion: HBO therapy resulted in increased VEGF expression in the defects even 2 weeks after the termination of treatment (6 weeks postsurgery)
ISSN
:
1079-2104
Journal Name
:
Oral Surgery Oral Medicien Oral Pathology Oral Radiology Endodontics
Volume
:
105
Issue Number
:
0
Publishing Year
:
1429 AH
2008 AD
Article Type
:
Article
Added Date
:
Sunday, August 12, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
أحمد محمد سعيد جان
Jan, Ahmed Mohammed Saeed
Researcher
Doctorate
amjan@kau.edu.sa
Files
File Name
Type
Description
34105.pdf
pdf
Ahmed Jan VEGF OOOOE 2008
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